Are the genes currently reported to be associated with Brugada Syndrome clinically valid?
The study challenges the clinical validity of nearly all genes currently tested and reported to be associated with Brugada Syndrome, highlighting the need for rigorous evidence-based evaluation before clinical use.
Our results contest the clinical validity of all but 1 gene clinically tested and reported to be associated with BrS. These findings warrant a systematic, evidence-based evaluation for reported gene-disease associations before use in patient care.
Hosseini et al. (2018) studied this question.