Proposed Diagnostic Criteria for the Brugada Syndrome

Figures

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  Figure 1. Structure of human voltage‐gated sodium Channel 1.5. Domains (D1–D4) of the alpha subunit of Nav1.5 are in red, yellow, green, and blue colors, respectively; IFMT motifs; and beta subunits are in gray. [Color figure can be viewed at wileyonlinelibrary.com]

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  Figure 2. Action potential of cardiac muscle cell shown in different phase w.r.t. time and membrane potential (mV). [Color figure can be viewed at wileyonlinelibrary.com]

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  Figure 3. Late and peak INa in physiologic and pathological conditions. [Color figure can be viewed at wileyonlinelibrary.com]

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  Figure 4. Different SGLT2is chemical structures.

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  Figure 5. Full structure of Nav1.5 bound with dapagliflozin drug. (A) Top view‐ Nav1.5 in blue color, dapagliflozin in red, membrane in light blue or sky color, water in orange color. (B) Side view of the system in the same color pattern. [Color figure can be viewed at wileyonlinelibrary.com]