Antifungal activity of pyranone and furanone derivatives, isolated from Aspergillus sp. IFM51759, against Aspergillus fumigatus

Thirty-five of 102 extracts obtained from freshly isolated fungal strains showed the antifungal activity against either pathogenic filamentous fungi or pathogenic yeasts. The extract of Aspergillus sp. IFM51759 (Aspergillus versicolor group), which showed the characteristic antifungal activity against Aspergillus fumigatus, one of the major opportunistic human pathogen causing APBA etc., prompted us to isolate antifungal compounds. A new furanone derivative, epimusacin D (1), was isolated along with three known pyranone derivatives, asperlin (2), acetylphomalactone (3), and the diastereomer of asperlin (4). The structure of epimusacin D (1) was determined from the analysis of the spectroscopic investigation. The antifungal activity of the above four compounds were discussed.