Analyzing genetic changes in vancomycin-intermediate Staphylococcus aureus reveals adaptive resistance mechanisms, suggesting important implications for treatment strategies.
The absence of canonical metabolic defects characteristic of SCVs, together with widespread alterations in regulatory and surface genes, is aligned with the concept that SCVs represent heterogeneous adaptive phenotypes rather than phenotypes defined primarily by specific metabolic deficiencies. The strain described here provides an example of a bacterial response that may contribute to both resistance and persistence under prolonged antibiotic pressure.
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Urushibara et al. (2026) studied this question.
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