Systematic review shows melatonin's benefits in spine surgery, suggesting need for further studies.
Melatonin demonstrates variable utility following spine surgery, with generally consistent anxiolysis and frequent benefit versus placebo but less consistent and comparatively weaker efficacy relative to active pharmacologic comparators. Future outcome-homogenous studies incorporating more granular, expansive comparator arms and more robust quantitative analyses are needed to further elucidate melatonin's role in advancing spine care.
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Yazdanpanah et al. (2026) studied this question.
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