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This research aims to investigate the relationship between diaschisis and cognitive deficits following stroke.

April 19, 2026Neurobiology of DiseaseOpen Access

Targeting diaschisis to alleviate memory deficits after experimental stroke

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Experimental evidence demonstrates that targeting diaschisis alleviates memory deficits after stroke, suggesting new treatment avenues.

This research aims to investigate the relationship between diaschisis and cognitive deficits following stroke.
Conducted small unilateral photothrombotic stroke in murine motor cortex.
Assessed bilateral excitability using c-Fos labelling.
Evaluated object memory and working memory performance.
Applied eslicarbazepine acetate to test its effects on excitability and cognition.
Small stroke lesions caused significant bilateral hyperexcitability.
Marked deficits were observed in object memory, with no impairment in working memory.
Treatment with eslicarbazepine acetate normalized excitability and improved object memory.

Adenauer et al. (2026) studied this question.

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