Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2025 update of the EULAR recommendations for the management of rheumatoid arthritis

Key Points

The research aims to update the evidence on the efficacy of DMARDs and glucocorticoids for rheumatoid arthritis management.
Conducted a systematic literature review using Medline, Embase, Cochrane, and Web of Science.
Included randomized controlled trials of csDMARDs, bDMARDs, and tsDMARDs published from January 2022 to January 2025.
Reviewed evidence on DMARDs for RA-associated interstitial lung disease and RA prevention in at-risk populations.
Identified 12,567 references with 390 full-texts reviewed and 72 studies included in the final analysis.
Evaluated various DMARDs including csDMARDs, bDMARDs, and tsDMARDs across phase 2 to phase 4 RCTs.
Provided insights for updating EULAR recommendations for RA management based on existing and novel treatments.

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Systematic literature review updates DMARD and glucocorticoid efficacy for rheumatoid arthritis management recommendations.

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Konzett et al. (2026) studied this question.

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