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April 19, 2026International Journal of Molecular MedicineOpen Access

Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)

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Authors

TZTaimin ZhangXZXi ZhangYXYaru Xie

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Overview

Review highlights metabolic-epigenetic interactions influencing cell death in diabetic kidney disease, suggesting new therapeutic avenues.

Key Points

  • This review aims to explore how glycolytic lactylation affects renal cell death pathways in diabetic kidney disease.
  • Comprehensive literature review on lactylation and its role in diabetic kidney disease.
  • Analysis of lactate's dual role as a metabolic byproduct and signaling molecule.
  • Discussion of the interplay between lactylation, ferroptosis, autophagy, and fibrosis.
  • Lactylation influences pathological processes like ferroptosis and autophagy in diabetic kidney disease.
  • The review suggests that targeting the glycolysis-lactylation pathway may have therapeutic potential.
  • Establishes a conceptual framework for future diagnostic and treatment strategies related to lactylation.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69e4713b010ef96374d8dd31https://doi.org/10.3892/ijmm.2026.5831
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