Novel prebiotics improve gut health by enhancing probiotics in a murine model, suggesting a new nutritional approach.
Key Points
The aim is to develop a novel prebiotic using protein hydrolysates and oligosaccharides to support gut probiotics more effectively than traditional prebiotics.
Created Maillard conjugates of 2′-fucosyllactose and potato protein hydrolysate.
Assessed the resistance of conjugates to gastrointestinal digestion.
Evaluated effects on gut microbiota in a 5-week murine model comparing against saline and conventional prebiotics.
Significantly increased abundance of Bifidobacteria and SCFAs-producing genera.
Enhanced colonic SCFAs levels compared to control.
Showed improvement in gut barrier markers and reduced hepatic fat accumulation.