Observational research identifies biomarkers predicting rheumatoid arthritis onset in seronegative individuals, suggesting targeted prevention opportunities.
These novel biomarkers can identify pre-symptomatic, seronegative individuals at high risk of RA onset and support their recruitment into trials for personalised prevention. Additionally, they distinguish early seronegative RA from OA with high specificity.
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Sareila et al. (2026) studied this question.
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