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January 17, 2016Diagnostyka Laboratoryjna

Anti-cyclic citrullinated peptide (anti-CCP) antibodies have a specificity for RA of about 98% and can be present years before clinical signs, heralding erosive changes.

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Why the study?

What are the key serological, genetic, and molecular markers for the early diagnosis of rheumatoid arthritis?

Population

Patients with or at risk for rheumatoid arthritis

Design

Review

Authors

BPBeata PolińskaJMJoanna Matowicka-KarnaHKH Kemona

Discussion

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Overview

Anti-CCP testing may flag preclinical RA risk; leaves open optimal multi-marker panels for early diagnosis.

Structured PICO

What are the key serological, genetic, and molecular markers for the early diagnosis of rheumatoid arthritis?

P
Population
Patients with or at risk for rheumatoid arthritis
I
Intervention
Diagnostic and prognostic markers including neopterin, anti-CCP antibodies, anti-CarP, anti-Sa/anti-MCV, genetic tests (e.g., C1858T in PNPN22), and miRNAs
O
Outcome
Diagnosis and disease activity of rheumatoid arthritissurrogate

Various serological, genetic, and molecular markers, particularly anti-CCP antibodies, are crucial for the early diagnosis and prognosis of rheumatoid arthritis.

Cite This Study

Polińska et al. (2016) studied this question.

synapsesocial.com/papers/6a905cdecf419109ed2781e8https://doi.org/10.5604/01.3001.0008.2523
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients2007 · 48 citations
  2. 2Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion2015 · 117 citations
  3. 3Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance?2009 · 44 citations
  4. 4A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis2011 · 158 citations