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April 19, 2026Annals of African Medicine0 citations

Hyperglycemia with Ketoacidosis following Acute Necrotizing Pancreatitis: A Case Suggestive of Pancreatogenic Diabetes

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PYPonvijaya YadavAHAvuthu HemanjaliDSDivam Prakash Singh

Key Points

  • The objective is to investigate hyperglycemia and ketoacidosis resulting from acute necrotizing pancreatitis and its implications for diabetes.
  • Clinical evaluation of a 44-year-old female with severe abdominal pain and vomiting.
  • Laboratory tests for blood glucose, ketones, and metabolic acidosis.
  • Imaging studies using computed tomography to assess pancreatitis severity.
  • Monitoring of blood sugar and vital signs in the intensive care unit.
  • Significant hyperglycemia of 440 mg/dL along with ketonuria and metabolic acidosis.
  • Elevated amylase and lipase levels consistent with pancreatitis.
  • Imaging showed 70%-80% necrosis of the pancreas.
  • The patient stabilized and improved clinically, leading to discharge with insulin and medication.

Abstract

A 44-year-old female, known case of hypertension and hypothyroidism, presented with severe epigastric pain and vomiting. Laboratory evaluation showed significant hyperglycemia (440 mg/dL), ketonuria, and metabolic acidosis (pH - 7.3, HCO - 10.6 mEq/L), consistent with Diabetic Ketoacidosis. Amylase and lipase levels were elevated. Imaging showed acute necrotising pancreatitis with 70%-80% necrosis (modified Computed tomography severity score inde × 8/10). The patient was shifted to the intensive care unit, where blood sugar levels and hypertension were strictly controlled. The patient was vitally stable and had shown significant clinical improvement. She was discharged on injectable insulin, oral antihypertensive and hypothyroid medication and is on regular follow-up.

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Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/69e472d8010ef96374d8ed38https://doi.org/10.4103/aam.aam_735_25
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