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April 19, 2026Scientific ReportsOpen Access

Intestinal epithelial cell-specific deletion of Jak2 disrupts gut homeostasis

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Authors

BDBrooke D’MelloUniversity Health NetworkDRD RiveraUniversity Health NetworkSRSonia RehalUniversity Health Network

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Implication

In vivo analysis reveals that IEC-specific Jak2 deletion disrupts gut integrity, suggesting a critical mucosal role for JAK2.

Key Points

  • This research investigates the role of JAK2 in maintaining epithelial barrier function in the gut.
  • Generated mice with IEC-specific Jak2 deletion using the Villin-Cre system.
  • Monitored mice for structural and inflammatory changes in intestinal tissue.
  • Conducted histological analysis and assessed intestinal permeability and cytokine expression.
  • Evaluated the impact of DSS-induced colitis in Jak2-deficient mice.
  • Jak2-deficient mice exhibited shortened colons and mild small intestinal inflammation at 12 weeks.
  • Histological assessment showed increased neutrophilic infiltration and epithelial damage in the small intestine.
  • JAK2 deficiency resulted in heightened intestinal permeability and altered expression of tight junction-related genes.
  • Mice with Jak2 deletion experienced sex-dependent weight loss under DSS-induced colitis conditions.

Cite This Study

D’Mello et al. (2026) studied this question.

synapsesocial.com/papers/69e47321010ef96374d8ef88https://doi.org/10.1038/s41598-026-48711-z
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