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The objective is to evaluate the application of causal inference methods in dementia research to inform future methodological innovations.

April 19, 2026Systematic ReviewsOpen Access

Causal inference in real-world dementia research: a systematic review protocol

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This systematic review examines causal inference applications in dementia research, highlighting methodological challenges and innovations.

The objective is to evaluate the application of causal inference methods in dementia research to inform future methodological innovations.
Conduct literature searches in databases such as MEDLINE, EMBASE, and others following PRISMA guidelines.
Include observational studies using causal inference methods related to cognitive decline and quality of life.
Extract data on study characteristics, methodologies, and key findings, assessing risk of bias with ROBINS-I.
Perform narrative synthesis and meta-analyses as appropriate to summarize results.
Anticipated identification of methodological gaps and trends in causal inference methods.
Emerging techniques such as machine learning may highlight future pathways in dementia research analysis.

Yang et al. (2026) studied this question.

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This systematic review examines causal inference applications in dementia research, highlighting methodological challenges and innovations.