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April 19, 2026Cancer Research

Abstract LB288: KDM4A mediated chromatin remodeling promotes tumor progression and immune modulation in malignant pleural mesothelioma

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Authors

SSSrinivasVinod SaladiHVHarshini VemulaMSMartin Sattler

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Overview

Transcriptomic analysis reveals KDM4A's role in immune response and tumor growth in malignant pleural mesothelioma, suggesting novel therapies.

Key Points

  • This research aims to define the role of KDM4A in malignant pleural mesothelioma and its effects on tumor progression and immune modulation.
  • Transcriptomic analysis following downregulation of KDM4A
  • ChIP-seq for H3K9me3 deposition on target genes
  • Dual inhibition assays of KDM4A and WNT pathways in cell lines
  • Evaluation of tumor growth in patient-derived xenografts
  • KDM4A knockdown reactivated innate immune response genes and inhibited WNT target gene expression.
  • Inhibition of KDM4A decreased expression of DNA repair genes.
  • Combining KDM4A inhibition with WNT inhibitors showed synergy in MPM cell lines.
  • KDM4A-specific inhibitors resulted in cell death and reduced tumor growth in xenografts.

Cite This Study

Saladi et al. (2026) studied this question.

synapsesocial.com/papers/69e4734c010ef96374d8f242https://doi.org/10.1158/1538-7445.am2026-lb288
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