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June 3, 2026Shengming kexue

Research progress of histone lysine demethylase 5A in tumors

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Authors

TLTianyu LiuJHJing HuHBHan Bing-she

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Overview

Review reveals KDM5A's roles in tumor growth and therapy resistance, suggesting it as a therapeutic target.

Key Points

  • This review aims to synthesize the roles of KDM5A in tumor biology, particularly in cancer progression and therapy resistance.
  • Comprehensive review of literature on KDM5A's molecular mechanisms and role in cancer
  • Analysis of KDM5A interactions with tumor immunotherapy and therapeutic inhibitors
  • Discussion on preclinical applications of KDM5A inhibitors in overcoming drug resistance
  • KDM5A is frequently dysregulated in malignancies, promoting tumor proliferation and migration via the PI3K/AKT pathway
  • KDM5A enhances tumor cell survival by downregulating pro-apoptotic genes, while also suppressing anti-tumor immunity
  • KDM5A inhibitors show efficacy in inhibiting tumor growth and overcoming drug resistance in model systems.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc3a6dee9eb8c0dce52adhttps://doi.org/10.3724/cbls.2026028
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