What question did this study set out to answer?

The review aims to explore the role of lactylation in mitochondrial quality control (MQC) and its implications for health and disease.

Research progress on the role of protein lactylation in mitochondrial quality control

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Review summarizes lactylation's impact on mitochondrial quality control mechanisms, suggesting potential therapeutic strategies.

The review aims to explore the role of lactylation in mitochondrial quality control (MQC) and its implications for health and disease.
Summarized advances in molecular mechanisms of lactylation related to MQC.
Analyzed effects of lactylation on mitochondrial structure, dynamics, and function.
Lactylation alters mitochondrial structure and metabolism through modifications of key proteins like VDAC1 and MDH2.
It promotes Drp1-dependent mitochondrial fission while its effect on fusion is unclear.
Lactylation exhibits both promoting and inhibiting effects on mitophagy, highlighting its complex regulatory role.

WANG et al. (2026) studied this question.

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