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The aim is to develop personalized immunotherapy targeting gastric cancer through T cell expansion and interaction with tumor models.

Abstract LB412: Reprogramming immunity: Personalized T cell approaches in gastric cancer

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The aim is to develop personalized immunotherapy targeting gastric cancer through T cell expansion and interaction with tumor models.
Generated tumor-reactive T cells from patient lymphocytes and tumor organoids.
Measured T cell activity using high-throughput imaging and flow cytometry.
Conducted single-cell RNA and TCR sequencing to analyze T cell features.
Used AI models to identify neoantigens relevant to patient-specific responses.
Developed a co-culture platform to mimic the tumor microenvironment.
Functional CD8+ T cells with high activation marker expression were generated.
Tumor-specific cytotoxicity, including effective organoid killing, was achieved.
Exposure to CAF-released factors reduced the activity of tumor-reactive T cells.
A physiologically relevant co-culture system was established for studying T cell efficacy.
Insights into drug resistance and immune evasion mechanisms were gained.

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Novel strategies enhance T cell-mediated tumor killing in gastric cancer, suggesting effective immunotherapy options.

Milardi et al. (2026) studied this question.

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