Characterization and Clinical Management of Adverse Events Following Treatment with Repotrectinib: A TRIDENT-1 Analysis

Alexander E. Drilon; B Cho; D Ross Camidge; Misako Nagasaka; Benjamin Besse; B Solomon; Koichi Goto; Jürgen Wolf; S Popat; Enriqueta Felip; Nong Yang; A. de Langen; Shun Lu; Vamsidhar Velcheti; Andrew Lin; C. Calvet; Li Li; Marina Tschaika; Salman Afsar; Haisu Yang; Jessica J. Lin

doi:10.1093/oncolo/oyag137

Key Points

This research aims to characterize and manage adverse events following treatment with repotrectinib.
Analyzed adverse events associated with repotrectinib treatment.
Evaluated the effectiveness of dose modifications.
Assessed pharmacologic interventions for managing neurological adverse events.
Many adverse events were identified following repotrectinib treatment.
Neurological adverse events were mitigated with appropriate management strategies.
Dose modifications and pharmacologic interventions proved effective in managing adverse events.

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Implication

Analysis reveals effective management for adverse events in patients treated with repotrectinib, indicating potential benefits in clinical settings.

Abstract

Many repotrectinib AEs, including neurological AEs secondary to TRK inhibition, were mitigated with appropriate management, including dose modification and/or pharmacologic intervention.

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Cite This Study

Drilon et al. (2026) studied this question.

synapsesocial.com/papers/69e473de010ef96374d8fa36 https://doi.org/10.1093/oncolo/oyag137

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Characterization and Clinical Management of Adverse Events Following Treatment with Repotrectinib: A TRIDENT-1 Analysis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Characterization and Clinical Management of Adverse Events Following Treatment with Repotrectinib: A TRIDENT-1 Analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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