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April 19, 2026Seminars in Cancer BiologyOpen Access

Therapy-driven clonal dynamics in chronic lymphocytic leukemia

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Authors

LMLarry MansouriKarolinska InstitutetTCThomas ChatzikonstantinouCentre for Research and Technology HellasLSLydia ScarfòVita-Salute San Raffaele University

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Implication

This review highlights clonal evolution and resistance mechanisms in chronic lymphocytic leukemia, suggesting advancements in personalized therapy.

Key Points

  • The review aims to summarize the dynamics of clonal evolution and therapeutic resistance in chronic lymphocytic leukemia (CLL).
  • Reviewed high-resolution genomic profiling results in CLL
  • Analyzed mechanisms of resistance to chemoimmunotherapy and targeted therapies
  • Discussed emerging technologies like single-cell sequencing and multi-omics approaches
  • Identified genetic alterations affecting signaling pathways and cellular processes
  • CLL shows complex clonal architecture influenced by therapy
  • Resistance mechanisms include TP53 aberrations and expansion of microclones
  • Distinct mutations like BTK and PLCG2 arise with targeted therapy
  • Emerging technologies can enhance understanding of clonal evolution and resistance

Cite This Study

Mansouri et al. (2026) studied this question.

synapsesocial.com/papers/69e473de010ef96374d8fa43https://doi.org/10.1016/j.semcancer.2026.04.001
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