What question did this study set out to answer?

This study analyzes the genomic clonality in patients with metastatic lung-limited non-small cell lung carcinoma who underwent double lung transplantation, aiming to identify tumor evolution patterns.

April 19, 2026Cancer Research

Abstract CT251: Genomic clonality analysis of patients with metastatic lung-limited non-small cell lung carcinoma (NSCLC) who underwent double lung transplantation (DLT) across timepoints and tumor region

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Authors

YCYoung Kwang ChaeNorthwestern University SKSanghwa KimNorthwestern University LCLiam Il‐Young ChungNorthwestern University

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Implication

DREAM study evaluates genomic clonal evolution in metastatic lung-limited NSCLC post double lung transplantation, suggesting a common tumor origin.

Key Points

This study analyzes the genomic clonality in patients with metastatic lung-limited non-small cell lung carcinoma who underwent double lung transplantation, aiming to identify tumor evolution patterns.
Included patients with advanced bilateral lung-limited NSCLC who underwent double lung transplantation.
Next generation sequencing (NGS) data was collected from diagnosis, explant, and recurrence.
Common truncal mutations were identified across all tumor samples.
Among 18 patients, 11 with bilateral NGS were analyzed showing common gene mutations.
7 patients had NGS data from 2 or more timepoints, 3 from 3 or more timepoints.
All patients exhibited common oncogenic genomic clones indicating a monoclonal origin.

Cite This Study

Chae et al. (2026) studied this question.

synapsesocial.com/papers/69e473ff010ef96374d8fcbd https://doi.org/10.1158/1538-7445.am2026-ct251

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Implication

DREAM study evaluates genomic clonal evolution in metastatic lung-limited NSCLC post double lung transplantation, suggesting a common tumor origin.

Abstract CT251: Genomic clonality analysis of patients with metastatic lung-limited non-small cell lung carcinoma (NSCLC) who underwent double lung transplantation (DLT) across timepoints and tumor region

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract CT251: Genomic clonality analysis of patients with metastatic lung-limited non-small cell lung carcinoma (NSCLC) who underwent double lung transplantation (DLT) across timepoints and tumor region

Discussion

Member takes

Implication

Key Points

Cite This Study

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