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April 19, 2026Cancer Research

Abstract LB195: Beyond hydrolase: Lactylation converts ABHD6 into a mitochondrial regulator of lenvatinib resistance in HCC

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Authors

ZTZhiyuan TangYSYuening SunCLChengju Luo

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Overview

Demonstrates that lactylation modifies ABHD6, affecting lenvatinib resistance in HCC, suggesting new treatment strategies.

Key Points

  • The research aims to understand how ABHD6 contributes to lenvatinib resistance in hepatocellular carcinoma and explores potential treatments.
  • Identified ABHD6 as a driver of lenvatinib resistance through metabolic adaptations.
  • Analyzed the impact of lactylation on ABHD6 function and mitochondrial localization.
  • Examined the effect of inhibiting lactate production and allosteric site occupancy on resistance.
  • ABHD6 functions as a scaffolding protein when lactylated, preventing drug-induced cell death.
  • Lactate production increases ABHD6 lactylation, promoting mitochondrial fission disruption.
  • Targeting lactate levels and the S148 catalytic site can restore drug sensitivity.

Cite This Study

Tang et al. (2026) studied this question.

synapsesocial.com/papers/69e4741c010ef96374d8fd1ehttps://doi.org/10.1158/1538-7445.am2026-lb195
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