Design, synthesis, nematicidal activity, and preliminary mechanism of pyrimidine derivatives through the scaffold hopping strategy

Tingting Du; Yan Zhang; Siyu Lu; Qiuxia Yang; Jixiang Chen

doi:10.1002/ps.70810

April 16, 2026Pest Management Science

Design, synthesis, nematicidal activity, and preliminary mechanism of pyrimidine derivatives through the scaffold hopping strategy

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Key Points

The aim is to synthesize and evaluate novel pyrimidine derivatives as effective nematicides.
Designed and synthesized pyrimidine derivatives using a scaffold hopping strategy.
Assessed nematicidal activity against nematodes in laboratory conditions.
Optimized scaffold structure for enhanced effectiveness.
Identified promising pyrimidine derivatives with significant nematicidal activity.
Demonstrated the potential of the scaffold for developing new compounds.

Implication

Demonstrates the efficacy of pyrimidine derivatives in nematicidal activity, indicating potential for new pest solutions.

Abstract

This scaffold can serve as the core structure for discovery of novel nematicides. We continue to optimize this scaffold structure, aiming to discover highly effective novel nematicides in future research.

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Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/69e4741c010ef96374d8fd54 https://doi.org/10.1002/ps.70810

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Design, synthesis, nematicidal activity, and preliminary mechanism of pyrimidine derivatives through the scaffold hopping strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, nematicidal activity, and preliminary mechanism of pyrimidine derivatives through the scaffold hopping strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

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