Potent Liver-Tropic mRNA Lipid Nanoparticles Helper and ionizable lipids play a crucial role in determining apolipoprotein E (ApoE) binding and subsequent liver tropism and low-density lipoprotein receptor (LDLR) mediated uptake. Ionizable lipids primarily govern the LDLR-independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver. More details can be found in the Research Article by Ashish Sarode, Shrirang Karve, and co-workers (DOI: 10.1002/adma.202517893).
Sarode et al. (Wed,) studied this question.