What question did this study set out to answer?

To evaluate the safety and efficacy of overnight orthokeratology in patients with stable mild-to-moderate keratoconus.

April 19, 2026International OphthalmologyOpen Access

Orthokeratology for stable mild-to-moderate keratoconus: a pilot study on safety and corneal remodeling via quantitative OCT analysis

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Authors

CZChang ZhangTongde Hospital of Zhejiang Province ZHZhenxian HuTongde Hospital of Zhejiang Province WLWenwei LiTongde Hospital of Zhejiang Province

Discussion

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Implication

A pilot study assesses improvements in visual acuity and corneal structure in mild-to-moderate keratoconus with orthokeratology, suggesting its viability as a non-surgical treatment.

Key Points

To evaluate the safety and efficacy of overnight orthokeratology in patients with stable mild-to-moderate keratoconus.
Conducted a prospective single-center cohort study with 13 patients (24 eyes) fitted with Ortho-K lenses.
Monitored clinical outcomes, including uncorrected and best-corrected visual acuity, corneal thickness, and refractive error over 18 months.
Utilized optical coherence tomography (OCT) for quantitative analysis of Bowman’s layer and other corneal parameters.
Significant improvement in uncorrected visual acuity from logMAR 0.59 to 0.19 (p < 0.05).
Mean myopic refraction decreased from -2.46 D to -0.62 D (p < 0.05).
Significant central corneal epithelial thinning and paracentral thickening observed (p < 0.05).
No significant changes in the cross-sectional area of Bowman’s layer or axial length during the study.
Minor adverse events reported, with issues like nocturnal glare and dry eyes leading to a few patient dropouts.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69e47440010ef96374d90082 https://doi.org/10.1007/s10792-026-04079-7

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Implication

A pilot study assesses improvements in visual acuity and corneal structure in mild-to-moderate keratoconus with orthokeratology, suggesting its viability as a non-surgical treatment.

Orthokeratology for stable mild-to-moderate keratoconus: a pilot study on safety and corneal remodeling via quantitative OCT analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Orthokeratology for stable mild-to-moderate keratoconus: a pilot study on safety and corneal remodeling via quantitative OCT analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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