Feasibility of umbilical cord blood as a source of red blood cell transfusion in preterm infants.

Elsa García González; Miguel Alsina Casanova; Dinara Samarkanova; Victoria Aldecoa‐Bilbao; Marta Teresa‐Palacio; Elisenda Farssac Busquets; J. Figueras Aloy; MaDolors Salvia-Roigés; Sergi Querol

doi:10.2450/2020.0169-20

November 1, 2021Open Access

Feasibility of umbilical cord blood as a source of red blood cell transfusion in preterm infants.

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Key Points

To determine the feasibility of preparing red blood cells from umbilical cord blood and identify the preterm infant cohort most likely to benefit from these transfusions.
Evaluated transfusion requirements and clinical morbidities among preterm infants to select an optimal recipient population.
Assessed blood bank collection and processing capabilities to determine if adequate red blood cell yields could be manufactured from umbilical cord blood.
Extremely low gestational age neonates were identified as the primary target population with the highest expected clinical benefit from cord blood-derived transfusions.
The blood bank successfully manufactured sufficient quantities of red blood cells from umbilical cord blood units to meet transfusion requirements.

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Implication

Feasibility study demonstrates sufficient red blood cell production from umbilical cord blood for extremely low gestational age neonates, indicating a potential alternative to adult donor blood.

Abstract

Considering the data obtained about RBC transfusion needs and morbidities, the ELGAN group has been identified as the target group that would benefit most from UCB-RBC transfusions. We have demonstrated that our blood bank is able to produce enough RBC from UCB. Randomised control trials are warranted to study the potential benefits of UCB compared to adult blood for RBC transfusions.

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González et al. (2021) studied this question.

synapsesocial.com/papers/69e48a1761e1519c6da470c9 https://doi.org/10.2450/2020.0169-20

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Feasibility of umbilical cord blood as a source of red blood cell transfusion in preterm infants.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Feasibility of umbilical cord blood as a source of red blood cell transfusion in preterm infants.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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