Both isolated office hypertension and masked hypertension are associated with structural cardiac alterations, highlighting the need for out-of-office BP monitoring to identify at-risk patients.
Isolated office hypertension has a noticeable prevalence in the population and is accompanied by structural cardiac alterations, suggesting that it is not an entirely harmless phenomenon. This is the case also for the opposite condition, that is, normal office but elevated home or ambulatory blood pressure, which implies that limiting blood pressure measurements to office values may not suffice in identification of subjects at risk.
Sega et al. (2001) studied this question.