Designing comprehensive and impactful implementation strategies for cancer-associated thrombosis prevention

Despite strong evidence and professional society recommendations for interventions to reduce cancer-associated thrombosis, uptake in clinical practice remains low. Implementation science offers structured approaches to close this evidence-to-practice gap. Frameworks such as the Implementation Research Logic Model and Consolidated Framework for Implementation Research guide identification of barriers, selection of strategies to address the barriers, and evaluation of clinical and implementation outcomes. Herein, the application of implementation science to close the gap between evidence for cancer-associated thrombosis prevention and use in clinical practice is discussed. Multi-level strategies, including clinician and patient education and electronic health record decision support, are essential to improve adoption. Clinical programs such as the Vermont Model demonstrate feasibility but highlight challenges in sustainability and scale-up. Integrating recommended cancer-associated prevention interventions into routine oncology care through tailored implementation strategies can reduce preventable morbidity and mortality, improving outcomes for patients with cancer.