Motion mitigation in positron-emission tomography guided radiotherapy delivered on a magnetic resonance imaging-linear accelerator

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Key Points

The aim is to enhance the accuracy of PET-guided radiotherapy by implementing a motion-robust pipeline using MRI and motion correction techniques.
Acquired PET images of a phantom under patient-derived breathing and static conditions.
Compared motion correction using MLMA with static and motion-blurred images.
Developed intensity-modulated radiation therapy plans for MR-linac with and without dynamic tracking methods.
Conducted dosimetry assessments using film measurements and evaluated gamma pass rates.
Motion-corrected PET showed smaller gross target volumes compared to motion-blurred images, more closely matching the static reference.
Gamma pass rates improved from 72% with motion correction to 90.3% with gating and up to 98.3% with MLC tracking.
Patient simulations indicated that motion-corrected plans significantly outperformed motion-blurred plans in terms of gamma pass rates.

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Demonstrates improved motion correction in PET-guided radiotherapy, suggesting enhanced treatment precision in cancer patients.

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Everard et al. (2026) studied this question.

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