MiR-1299 expression was significantly increased in acute myocardial infarction and demonstrated high diagnostic value with an AUC of 0.895, sensitivity of 77.65%, and specificity of 88.33%.
Case-Control (n=145)
No
Does miR-1299 have diagnostic value for acute myocardial infarction in patients with first-episode STEMI?
MiR-1299 is significantly elevated in patients with acute myocardial infarction, demonstrating high diagnostic value, and regulates myocardial injury markers in vitro.
Effect estimate: AUC 0.895
p-value: p=<0.001
Acute myocardial infarction (AMI) often occurs suddenly and leads to serious consequences. Therefore, there is an urgent need to find a new biomarker for AMI. MiR-1299 expression was measured by RT-qPCR. The diagnostic value of miR-1299 in AMI was measured by the receiver operating characteristic (ROC) curve. Chi-squared test was utilized to analyze associations between the clinicopathological characteristics of AMI patients and miR-1299 levels. MiR-1299 was overexpressed or inhibited by transfection in hypoxic H9c2 cells. Then, cell activity and the expression of myocardial injury markers in H9c2 cells were detected. MiR-1299 was increased in AMI and had a high diagnostic value in AMI. In AMI, the expression level of miR-1299 is closely related to WBC and current smoking. In hypoxic H9c2 cells, the overexpression of miR-1299 reduced the cell viability, while the inhibition of miR-1299 increased the cell viability. In addition, the overexpression of miR-1299 increased cTnⅠ, CK-MB, and MYO, while the inhibition of miR-1299 significantly reduced cTnⅠ, CK-MB, and MYO in hypoxic H9c2 cells. MiR-1299 was increased in AMI and had a high diagnostic value. In hypoxic H9c2 cells, miR-1299 regulated proliferation and the expression of myocardial injury markers, suggesting that miR-1299 may be a potential biomarker of AMI.
Dong et al. (Fri,) conducted a case-control in Acute myocardial infarction (n=145). miR-1299 biomarker assessment vs. Healthy individuals was evaluated on Diagnostic value of miR-1299 (Area Under the Curve) (AUC 0.895, p=<0.001). MiR-1299 expression was significantly increased in acute myocardial infarction and demonstrated high diagnostic value with an AUC of 0.895, sensitivity of 77.65%, and specificity of 88.33%.