Tungsten-mediated decarboxylative reaction forms C(sp3)–O bonds, indicating potential for bioactive molecules.
We reported herein a tungsten-catalyzed decarboxylative C(sp³)-O bond formation reaction under mild, base-free conditions with irradiation. This transformation employs readily available carboxylic acids as substrates and 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) as oxygenation reagent. The protocol exhibits a broad substrate scope and has been successfully applied to the late-stage functionalization of bioactive molecules.
No takes yet. Share an insight, caveat, or question.
He et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: