Researchers demonstrate a new probe that labels amyloid species, suggesting improved diagnostics for amyloid-related diseases.
A chemiluminescent amyloid-binding probe (CLIP-1) was developed and evaluated for its ability to label different amyloid species. CLIP-1 produced an oxygen-dependent chemiluminescence emission when bound to amyloid aggregates. This probe exhibited a different emission wavelength when bound to tau versus Aβ aggregates, which is attributed to differences in the relative charge of the amyloids at neutral pH. The cover image represents the CLIP-1 probe becoming chemiluminescent as it binds to amyloid fibrils. More details can be found in the Research Article by Jerry Yang and co-workers (DOI: 10.1002/cbic.202600008).
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Chung et al. (2026) studied this question.
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