Why the study?
Patients with NAFLD show increased cardiovascular risk, with adverse liver effects on cardiac function postulated as a mechanism, but cardiac morphology and function in morbidly obese patients required evaluation.
Is nonalcoholic steatohepatitis associated with adverse cardiac morphology and function in patients with morbid obesity?
Population
171 consecutive patients with morbid obesity referred for bariatric surgery without known cardiac disease
Comparison
NASH vs isolated steatosis vs without steatosis on liver biopsy
Design
Cross-sectional echocardiographic study
Authors
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NASH may signal elevated CV risk via LV remodeling in morbid obesity; hypothesis-generating and should not yet change practice.
Is nonalcoholic steatohepatitis associated with adverse cardiac morphology and function in patients with morbid obesity?
In patients with extreme obesity, NASH is associated with left ventricular concentric remodeling and hyperdynamic circulation, which may contribute to increased cardiovascular risk.
Styczyński et al. (2021) studied this question.
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