Preclinical study demonstrates aurantiamide acetate reduces paw swelling in arthritic rats and inhibits cathepsins, suggesting potential therapeutic utility for inflammatory joint disease.
Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.
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ISSHIKI et al. (2001) studied this question.
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