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October 13, 2025Bratislavské lekárske listy/Bratislava medical journalOpen Access

Aurantiamide Acetate Mitigates Hypertensive Cardiac Hypertrophy Through Modulation of MAPK Signaling and ER Stress

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Why the study?

Hypertensive cardiac hypertrophy significantly contributes to heart failure, but the impact of aurantiamide acetate on hypertensive cardiac hypertrophy remains unclear.

Does aurantiamide acetate mitigate hypertensive cardiac hypertrophy and ER stress in in vitro and in vivo models?

Population

Ang II- and TM-treated H9C2 cardiomyoblasts and 2K1C hypertensive rats

Comparison

Aurantiamide acetate administration

Design

In vitro and in vivo preclinical animal and cell study

Authors

TÇTuğçe ÇekerMAMutay AslanEKEsma Konuk

Discussion

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Overview

Hypothesis-generating for aurantiamide acetate in hypertensive heart disease; leaves open clinical translation pending human data.

Structured PICO

Does aurantiamide acetate mitigate hypertensive cardiac hypertrophy and ER stress in in vitro and in vivo models?

P
Population
H9C2 cardiomyoblasts with Ang II-induced hypertrophy and tunicamycin-induced ER stress (in vitro); rats with two-kidney, one-clip (2K1C) model of hypertensive hypertrophic cardiomyopathy (in vivo)
I
Intervention
Aurantiamide acetate (AA)
C
Comparator
Untreated models (implied)
O
Outcome
Cardiac hypertrophy, ER stress markers, and MAPK activationsurrogate

Aurantiamide acetate demonstrates therapeutic potential for hypertensive heart disease by mitigating cardiac hypertrophy through inhibition of MAPK signaling and ER stress.

Cite This Study

Çeker et al. (2025) studied this question.

synapsesocial.com/papers/6a1be8f9fc87fd06169cea66https://doi.org/10.1007/s44411-025-00383-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aurantiamide Acetate Mitigates Hypertensive Cardiac Hypertrophy via Modulation of MAPK Signaling and ER Stress2025
  2. 2Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway2016 · 71 citations
  3. 3Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo2014 · 31 citations
  4. 4Anacardic acid protects against phenylephrine-induced mouse cardiac hypertrophy through JNK signaling-dependent regulation of histone acetylation2020
  5. 5JNK signaling-dependent regulation of histone acetylation are involved in anacardic acid alleviates cardiomyocyte hypertrophy induced by phenylephrine2021 · 11 citations