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January 1, 2016International Journal of Biological SciencesOpen Access

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway

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Key result

Asiatic acid significantly inhibited cardiac hypertrophy and fibrosis induced by pressure overload or angiotensin II by activating the AMPKα signaling pathway.

Why the study?

Does Asiatic acid prevent cardiac hypertrophy and fibrosis in a mouse model of pressure overload?

Population

C57/B6 mice subjected to aortic banding to induce pressure overload, and neonatal rat cardiac…

Comparison

Asiatic acid 10 or 30 mg/kg orally for 7 weeks… vs Vehicle and sham surgery.

Design

Preclinical, All surgeries and subsequent analyses were performed in a blind…

Follow-up

7 weeks

Authors

ZMZhen‐Guo MaJDJia DaiWWWenying Wei

Discussion

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Overview

Hypothesis-generating in pressure-overload models; leaves open clinical translation of Asiatic acid.

Structured PICO

Does Asiatic acid prevent cardiac hypertrophy and fibrosis in a mouse model of pressure overload?

P
Population
Male C57/B6 mice aged 8-10 weeks subjected to aortic banding to induce cardiac hypertrophy and followed for 7 weeks.
I
Intervention
Asiatic acid (AA) 10 or 30 mg/kg orally for 7 weeks (in vivo) or 20 μM (in vitro).
C
Comparator
Vehicle (1% CMCNa for in vivo, 0.1% DMSO for in vitro) and sham surgery.
O
Outcome
Cardiac hypertrophy (assessed by HW/BW, HW/TL, myocyte cross-sectional area, and echocardiography) and cardiac fibrosis.surrogate

Main Result

p-value: p=<0.05

Asiatic acid protects against cardiac hypertrophy and fibrosis by activating the AMPKα signaling pathway in a preclinical model of pressure overload.

Limitations

  • Animal and in vitro model, requiring future studies for clinical application
  • Compound C used for AMPK inhibition has unspecific effects

Cite This Study

Ma et al. (2016) studied Cardiac hypertrophy. Asiatic acid vs. Vehicle was evaluated on Cardiac hypertrophy (HW/BW, HW/TL, cross-sectional area) (p=<0.05). Asiatic acid significantly inhibited cardiac hypertrophy and fibrosis induced by pressure overload or angiotensin II by activating the AMPKα signaling pathway.

synapsesocial.com/papers/6a93021ab38bf6ce534aa0f1https://doi.org/10.7150/ijbs.14213
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo2014 · 31 citations
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  4. 4Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction2015 · 28 citations
  5. 5Long‐term activation of adenosine monophosphate‐activated protein kinase attenuates pressure‐overload‐induced cardiac hypertrophy2007 · 123 citations