Key result
Asiatic acid treatment at 25 mg/kg/day significantly improved left ventricular ejection fraction (42.50% vs 31.50%) and attenuated cardiac remodeling in a rat model of myocardial infarction.
Why the study?
Does asiatic acid improve cardiac function and inhibit left ventricular remodeling in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction induced by coronary artery ligation
Comparison
Asiatic acid (AA) administered orally vs Vehicle-treated MI model rats and sham-operated…
Design
Preclinical
Follow-up
4 weeks
Authors
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May support further preclinical testing of asiatic acid post-MI; leaves open human translation.
Does asiatic acid improve cardiac function and inhibit left ventricular remodeling in a rat model of myocardial infarction?
Absolute Event Rate: 42.5% vs 31.5%
p-value: p=<0.05
Asiatic acid preserves cardiac function and attenuates left ventricular remodeling in a rat model of myocardial infarction, suggesting potential as a novel therapeutic agent.
Huo et al. (2015) studied Myocardial Infarction (n=120). Asiatic acid vs. Vehicle (5% DMSO) was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.05). Asiatic acid treatment at 25 mg/kg/day significantly improved left ventricular ejection fraction (42.50% vs 31.50%) and attenuated cardiac remodeling in a rat model of myocardial infarction.
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