Key result
Targeting shared cardiometabolic and genetic mechanisms may delay cardiovascular aging and promote longevity.
Why the study?
Many factors promoting atherosclerotic cardiovascular disease overlap with aging processes, and understanding genetic and molecular pathways may guide interventions to delay cardiovascular aging and promote longevity.
Understanding the genetic, molecular, and biochemical pathways of aging may help introduce interventions to delay cardiovascular aging and promote longevity.
Answers are grounded in this paper and cite their sources.
Should not yet change CV aging management; leaves open shared pathways as intervention targets pending dedicated trials.
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dyslipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goal of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations.
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Pietri et al. (2021) conducted a review in Cardiovascular aging and longevity. Cardiometabolic disorders and genetic modulators share common pathophysiological mechanisms with aging, suggesting that targeting these pathways may delay cardiovascular aging and promote longevity.
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