Why the study?
Does lamotrigine prolong QTc in healthy subjects?
Does lamotrigine prolong QTc in healthy subjects?
Lamotrigine at therapeutic doses (50-200 mg b.d.) does not prolong the QTc interval in healthy subjects.
No QT monitoring needed for therapeutic lamotrigine in healthy subjects; leaves open effects in patients with cardiac disease.
Therapeutic doses of lamotrigine (50-200 mg b.d.) were not associated with QT prolongation in healthy subjects.
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Dixon et al. (2008) studied this question.
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