Key result
Non-cardiac drugs, including terfenadine and astemizole, are associated with QT prolongation, torsades de pointes, and sudden death due to IKr channel blockade.
Why the study?
Do certain non-cardiac drugs increase the risk of QT prolongation and torsades de pointes?
Population
Patients taking non-cardiac drugs
Design
Review
Authors
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Highlights the underrecognized proarrhythmic risk of torsades de pointes associated with various non-cardiac drugs due to IKr channel blockade.
Do certain non-cardiac drugs increase the risk of QT prolongation and torsades de pointes?
Highlights the underrecognized proarrhythmic risk of torsades de pointes associated with various non-cardiac drugs due to IKr channel blockade.
Y. G. Yap (2000) conducted a review in Torsades de pointes. Non-cardiac drugs was evaluated. Non-cardiac drugs, including terfenadine and astemizole, are associated with QT prolongation, torsades de pointes, and sudden death due to IKr channel blockade.
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