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November 1, 2003American Journal of Therapeutics

QT Prolongation and Fatal Arrhythmias: A Review of Clinical Implications and Effects of Drugs

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Why the study?

What are the clinical implications and risk factors associated with drug-induced QT prolongation and torsades de pointes?

Population

Patients at risk for drug-induced torsades de pointes, including those with congenital long QT syndrome…

Design

Review

Authors

LCLuigi X. Cubeddu

Discussion

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Overview

Requires QT risk assessment before prescribing these agents; confirms known associations but leaves optimal mitigation open.

Structured PICO

What are the clinical implications and risk factors associated with drug-induced QT prolongation and torsades de pointes?

P
Population
Patients at risk for drug-induced torsades de pointes, including those with congenital long QT syndrome, female gender, hypokalemia, and use of sympathomimetics
I
Intervention
QT-prolonging drugs (including antiarrhythmics, macrolide and fluoroquinolone antibiotics, antipsychotics, antidepressants, triptans, cisapride, dolasetron)
O
Outcome
QT prolongation and torsades de pointessafety

Drug-induced QT prolongation is a significant clinical challenge that requires careful consideration of patient risk factors and drug interactions to prevent fatal arrhythmias.

Cite This Study

Luigi X. Cubeddu (2003) studied this question.

synapsesocial.com/papers/6a8157bf080e7f4ac74d6944https://doi.org/10.1097/00045391-200311000-00013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amiodarone Therapy After Previous Sotalol-induced Torsade de Pointes: Analysis of QT Dispersion to Predict Proarrhythmia1996 · 9 citations
  2. 2Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs1993 · 747 citations
  3. 3Amiodarone Induced Torsades de Pointes with Excessive QT Dispersion Following Quinidine Induced Polymorphic Ventricular Tachycardia1997 · 14 citations
  4. 4Proarrhythmic Effects of Intravenous Quinidine, Amiodarone, d -Sotalol, and Almokalant in the Anesthetized Rabbit Model of Torsade de Pointes2002 · 44 citations
  5. 5Drug Block of I Kr : Model Systems and Relevance to Human Arrhythmias2001 · 172 citations