Neuronal K(V)7 channels remain promising targets for CNS therapeutics, though further understanding of their molecular pharmacology and role in disease development is needed.
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Neuronal K(V)7 channels remain viable CNS targets; leaves open successful development pending detailed molecular pharmacology and disease-state analyses.
These channels continue to be valid and approachable targets for CNS therapeutics. However, we may need to understand more about the roles of neuronal K(V)7 channels during the development of disease states, as well as to pay more attention to a detailed analysis of the molecular pharmacology of the different channel subfamily members and the modes of interaction of individual modulators, in order to successfully target these channels for therapeutic development.
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Valentin K. Gribkoff (2008) studied this question.
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