Key result
Alternative splicing of KCNQ4 produces profound differences in voltage-dependent activation, with KCNQ4_v4 shifting activation leftward by approximately 20 mV compared with KCNQ4_v1.
Population
Inner ear-specific KCNQ4 channels (splice variants KCNQ4_v1-v4)
Comparison
Alternative splicing and mutations within the C… vs Comparison among different splice variants
Design
Preclinical
Authors
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Hypothesis-generating for KCNQ4 splicing in hearing loss; leaves open human relevance and clinical translation.
Alternative splicing of KCNQ4 channels produces profound differences in voltage-dependent phenotype and functional expression, providing insight into the mechanisms of nonsyndromic progressive high frequency hearing loss.
Xu et al. (2007) studied Nonsyndromic progressive high frequency hearing loss. Alternative splicing of KCNQ4 (KCNQ4_v1-v4) vs. KCNQ4_v1 was evaluated on Voltage-dependent phenotype and functional expression of the channel. Alternative splicing of KCNQ4 produces profound differences in voltage-dependent activation, with KCNQ4_v4 shifting activation leftward by approximately 20 mV compared with KCNQ4_v1.
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