February 15, 2001Journal of NeuroscienceOpen Access

Differential Expression of KCNQ2 Splice Variants: Implications to M Current Function during Neuronal Development

View Full Paper

Ask AI

Bookmark

Population

Mammalian cells transfected with human KCNQ2 splice variants and KCNQ3; human brain tissues and…

Comparison

Transfection with KCNQ2 long and short splice… vs Different combinations of transfections

Design

Preclinical

Authors

JSJeffrey S. SmithUniversity of Virginia CIClaudia A. IannottiAstraZeneca (United States)PDPauline G. DargisWilmington University

Discussion

Member takes

Implication

May modulate developmental neuronal excitability; leaves open splice-variant roles in epilepsy pathogenesis.

Structured PICO

Population

Mammalian cells transfected with human KCNQ2 splice variants (Q2L, Q2S) and KCNQ3; human brain tissues and neuroblastoma cells for expression analysis

Intervention

Transfection with KCNQ2 long (Q2L) and short (Q2S) splice variants, alone or in combination with KCNQ3

Comparator

Different combinations of transfections (e.g., Q2L alone vs. Q2S alone vs. cotransfection)

Outcome

Potassium current characteristics (activation, inactivation, voltage dependence, and tetraethylammonium block)surrogate

Differential expression of KCNQ2 splice variants modulates neuronal excitability, with the short variant dampening potassium conductances in the developing brain.

Cite This Study

Smith et al. (2001) studied this question.

synapsesocial.com/papers/6a90320f1dcd98381b83ff6e https://doi.org/10.1523/jneurosci.21-04-01096.2001

View Full Paper

Ask AI

Bookmark

Differential Expression of KCNQ2 Splice Variants: Implications to M Current Function during Neuronal Development

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential Expression of KCNQ2 Splice Variants: Implications to M Current Function during Neuronal Development

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider