Population
Human brain tissue and COS cells
Design
Preclinical
Authors
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L-735,821 offers an in vitro probe for KCNQ2/3; leaves open whether blockade alters neonatal seizure phenotypes in vivo.
KCNQ2 and KCNQ3 potassium channels, linked to benign familial neonatal convulsions, are co-expressed in specific brain regions and can be blocked by L-735,821.
Tinel et al. (1998) studied this question.
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