November 14, 2006Circulation
Prevention of High-Dose Chemotherapy–Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition
Why the study?
Does early treatment with enalapril prevent the development of late cardiotoxicity in high-risk patients treated with high-dose chemotherapy?
Population
High-risk patients treated with high-dose chemotherapy (HDC), defined by an increased troponin I value
Authors
Discussion
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Member takes
Implication
May support troponin-guided enalapril in high-risk chemotherapy patients; leaves open need for randomized confirmation before practice change.
Structured PICO
Does early treatment with enalapril prevent the development of late cardiotoxicity in high-risk patients treated with high-dose chemotherapy?
P
Population
High-risk patients treated with high-dose chemotherapy (HDC), defined by an increased troponin I value
I
Intervention
Early treatment with enalapril
O
Outcome
Development of late cardiotoxicity
Early initiation of enalapril in patients receiving high-dose chemotherapy who develop elevated troponin I may prevent subsequent cardiotoxicity.
Cite This Study
Cardinale et al. (2006) studied this question.