Why the study?
Does the second-generation cTnT assay improve sensitivity for detecting myocardial infarction and other myocardial pathologies compared to the cTnI assay?
Does the second-generation cTnT assay improve sensitivity for detecting myocardial infarction and other myocardial pathologies compared to the cTnI assay?
Antemortem elevations in cTnT are highly sensitive for detecting histologic evidence of myocardial infarction and other pathologies.
May support preferring second-generation cTnT for myocardial injury detection; leaves open need for prospective validation before practice change.
All patients with increased serum CK-MB, cTnI, and cTnT had significant cardiac histologic changes. The second-generation cTnT assay appears to be a more sensitive indicator of MI and other myocardial pathologies than the cTnI assay used in this study.
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Ooi et al. (2000) studied this question.
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