Why the study?
Do vascular disorders increase the risk of incident dementia across different age groups?
Do vascular disorders increase the risk of incident dementia across different age groups?
Vascular disorders do not appear to be a risk factor for incident dementia at advanced ages, suggesting other mechanisms drive dementia risk in the oldest old.
May limit vascular interventions for dementia prevention in advanced age; leaves open dominant mechanisms in the oldest old.
We conclude that vascular disorders are no longer a risk factor for dementia at high age. Possible explanations include selective survival of individuals who are less susceptible to the negative consequences of vascular disorders and differences in follow-up time between individuals with and without a vascular disorder. Future research should focus on the identification of other risk factors than vascular disorders, for example, genetic or inflammatory processes, that can potentially explain the strong age-related increase in dementia risk.
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Legdeur et al. (2019) studied this question.
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