Transient Increase in Serum Uric Acid and Gout attacks after weight loss effect on Tirzepatide and Semaglutide

April 1, 2026AACE Endocrinology and DiabetesOpen Access

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This research aims to investigate the relationship between weight loss induced by GLP-1 receptor agonists and changes in serum uric acid levels.
Case series analysis of four adults undergoing GLP-1 RA or dual GIP/GLP-1 RA therapy.
Monitoring of serum uric acid levels over 3-5 months.
Assessment of weight loss and metabolic profiles, including glycemic and lipid levels.
Three out of four patients showed elevated uric acid levels within 3-5 months of starting therapy.
Two patients experienced acute gout flares, with one having recurrent episodes despite normal uric acid levels.
Despite significant weight loss and improved metabolic markers, uric acid levels remained elevated.

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Case series shows transient hyperuricemia and gout flares in adults after weight loss, suggesting monitoring is important.

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Chaaya et al. (2026) studied this question.

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