Mild mitral valve prolapse expression can evolve over time, with 25% of community individuals progressing to significant mitral regurgitation over 3 to 16 years.
NDM may evolve into MVP, highlighting the clinical significance of mild MVP expression. MVP progresses to significant mitral regurgitation over a period of 3 to 16 years in one-fourth of individuals in the community. Changes in mitral leaflet morphology are associated with both NDM and MVP progression.
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Delling et al. (2016) studied this question.
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